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GSTs consist of several classes of genes, and GSTM1 and GSTT1 polymorphisms have been investigated most intensively in relation to tobacco-related cancers [ 22].
COMT has been studied intensively in relation to several reward-motivated behaviours such as development of diet-induced obesity [27], [46].
Risk perception has been studied intensively in relation to environmental and technical-industrial risk.
The phenomenon of epithelial mesenchymal transition (EMT) (Kopfstein and Christofori, 2006) has been studied intensively in relation to metastasis.
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BKV has been most intensively studied in relation to bladder cancer as its major sites of persistence are the cells of the kidney and urinary tract (Jiang et al, 2009) and it induces nephropathy in renal transplant patients.
Among the class 3 semaphorins, Sema3A has been most intensively studied in relation to axon guidance [ 26] and intrathecally administered Sema3A protein attenuates neuropathic pain behavior in rats with chronic constriction injury of the sciatic nerve [ 27].
Because of the relevance of mtDNA for energy production and oxidative stress generation, mtDNA haplogroups and clusters have been intensively investigated in relation to aging and neurodegerative diseases characterized or accompanied by cognitive impairment, including Alzheimer's disease [ 10], and frontal lobe disease [ 11].
A 3×2 factorial experiment was used to evaluate the effects of added molybdenum (Mo) at the rate of 0, 4 or 8 ppm in the diet and two floor types (straw bedding or galvanised expanded metal) on 92 Texel cross intensively fed lambs in relation to hepatic copper levels and lamb growth.
This is accompanied by large numbers of small-seeded grasses, a strong reduction in goatgrass and a relative peak in wild barley that may have been intensively cultivated under sufficient moisture availability in relation to the previous shortcomings in AH VI.
Although less intensively studied, similar concerns have been expressed in relation to epidemiology, 24 25 pharmacoepidemiology, 26 diagnosis research, 27 prognosis research, 28 and preclinical research.
A novel biomarker in relation to cardiac fibrosis and remodeling that is currently intensively studied is galectin-3 [ 52].
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