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The UMS program has been subjected to intensive validation using the Protherm database and 3 proteins from retinal disease (rhodopsin, complement factor H, and RPE65 5.
Through an intensive validation process, the model was successfully analyzed and ranked the risks of different types.
Therefore, intensive validation studies, including multi-institutional research, are needed to establish the prognostic biomarkers from tumor site-specific genes.
A more recent intensive validation exercise has produced estimates of Sp of 97.3% for the I-ELISA, 98.2% for CHEKIT and 97.2% for the Ceditest (the C-ELISA).
Another computationally intensive validation approach is leave one out validation, an extreme case of cross validation with partitioning to the total number of instances.
We generated de novo transcriptome assemblies with annotated gene sets of two onion accessions using ISGAP, an automated pipeline, with intensive validation.
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The studies were subject to intensive replication, validation, and reanalysis that confirmed the original findings.
The original studies were subject to intensive replication, validation, and re-analysis which confirmed the original findings [ 84].
This approach allowed rapid, albeit preliminary, screening of many thousands of alloys and identification of promising candidate compositions, some of which are reported in this paper, for more time intensive experimental validations and assessments.
Since model selection is not based on evaluating prediction accuracy but on testing associations, FAM-MDR does not involve computationally intensive cross-validation steps.
Lastly, it was somewhat disappointing that after computationally intensive cross-validation and permutation-based significance assessment procedures only a single "best" epistasis model was proposed.
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