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An evolutionary response to intensive selection pressure imposed by density dependent survival and reproduction relies on genetic variants for adaptive evolution.
The current approach recognized that CSSV resistance breeding was a long-term aim whose final solution lay in the careful monitoring of growth and yield data of test plants in variety trials under intensive selection pressure.
If intensive selection pressure occurred only over a few generations, it is unlikely that recombination had an impact on haplotype structure, and thus it resulted in (extended) linkage disequilibrium (LD) patterns between the mutation and neighboring loci [ 1].
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Presumably, episodes of novel intensive selection pressures are not uncommon in nature [ 14, 15, 75].
The greater permissiveness of slightly deleterious events in vertebrates would allow the accumulation of redundant gene copies that would be purged under more intensive selection pressures (Lynch and Conery 2000).
Predation on chicks represents an intensive selective pressure.
The issue of increasing incidence of MDR is clearly more complex in intensive care units (ICUs), where selection pressure and emergence of resistance, as well as the risk of patient-to-patient transmission, are highest.
Although most fluoroquinolone use is in the community, the most intensive use and therefore the greatest selection pressure relative to numbers and concentration of patients is in hospitals.
The finding of higher resistance in isolates from ICU patients to most agents is not unexpected, given the high selection pressure exerted by intensive antimicrobial use in this setting and the ease of transmission of resistant pathogens on the hands of healthcare workers.
However, selection pressure analyses are computationally intensive and awkward to configure.
Among these families, some have undergone intensive expansions, others were submitted to a strong selection pressure to maintain them with similar numbers, with a very low divergence rate, across different plant genomes (Armisen et al. 2008).
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