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"A lot of people will buy a $30 million ocean front mansion, tear it down, and start all over again," explains Alan Fiocchi, founder of AlchemyRED, a company that project manages the ground-up construction or intensive remodeling of multi-million dollar estates around the world.
Mitochondria within healthy cells are often organized into a dynamic tubular and branched network that undergoes intensive remodeling in response to various stimuli related to cell death [9] [11] as well as metabolic and developmental processes [12].
In the medullary region, there is secondary cancellous bone produced by intensive remodeling.
The inflammatory cell infiltrate observed in chronic mucosal inflammation is associated with changes in epithelial proliferation and migration and accompanied by intensive remodeling of the subepithelial connective tissue, which in turn leads to increased turnover of extracellular matrix (ECM) components [ 1, 2].
The intensive remodeling of the calcified cartilage including the tide mark suggested that these cells originated from the subchondral bone area.
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In normal cells, DNA staining reveals completely uniform colour outlines, whereas senescent cells usually show dot-like patterns, known as senescence-associated heterochromatic foci (SAHF), which appear because of intensive remodelling in the chromatin and a lower susceptibility for digestion by nucleases.
In patulin-exposed males, an absence of primary vascular longitudinal bone tissue near the endosteal border was observed, which could be associated with intensive bone remodeling.
Furthermore, it is hard to see how processes like phagocytosis, which rely both on a large cell size and dramatic, energy-intensive membrane remodeling events could have occurred in an archaeal proto-eukaryote lacking mitochondria [ 1].
Normally, the radiographs taken with the faxitron machine revealed the location and direction of the drill hole, although at later time points (24 weeks) depending on the biomaterials bone healing could be so far advanced that detection proved to be difficult and only signs of intensive bone remodelling indicated the original bone defects.
Unlike in all previously discussed specimens, the cortex is subject to intensive Haversian remodeling, with only limited areas of primary cortex remaining.
However, it is strongly and rapidly upregulated in endothelial cells at sites of intensive vessel remodeling, including the female reproductive system and tumors [ 35].
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Justyna Jupowicz-Kozak
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