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We compared the statistical power of the current, intensive protocol with those of shorter duration and differing start date to generate general guidelines on sampling.
This computationally intensive protocol samples a considerable conformation space, and consequently is able to identify near-native models within the top-ranking clusters for many challenging cases.
Two of the subjects followed a more intensive protocol than the other subjects.
Sixty-nine patients were treated according to the intensive protocol, and 64 were submitted to autogeneic stem-cell transplantation (93%).
Secondary outcomes include patient quality of life, physician compliance with the intensive protocol, patient compliance with medication, and adverse effects.
The priority of the treatment targets can be changed during these visits, but not the choice between the two treatment options (ADDITION protocol or the less intensive protocol).
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We advocate the use of the Chao estimators as best for intensive protocols limited in space and time and the use of the asymptotic properties of the Michaelis Menten curve as a stopping or reliability rule, as it allows the investigator to know when a close-to-complete inventory has been obtained and when reliable non-parametric estimators have been achieved.
Many studies for intensive protocols in untreated GCT have employed large doses of bleomycin, making them unsuitable for salvage treatment.
The data suggest that older adolescents with high-risk HL require intensive protocols as primary therapy to secure optimal outcome.
Besides, researchers and participants in trials follow strict and often intensive protocols, which could also lead to better adherence by the participants, but this might not be financially and practically feasible in real-world primary care.
Any innovation that would afford intensive, inpatient control of glucose without undue hypoglycemia, including continuous intravascular glucose monitors, improved staff training in use of intensive protocols, and/or the use of experimentally validated treatment regimens, may improve outcomes in critically ill patients with hyperglycemia.
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