Future research should investigate whether more intensive or novel therapies such as CXCR4 antagonist can improve the poor prognosis of CXCR4-positive patients.
This indicator should be used to identify patients who are at high risk for metastasis; as such patients may be candidates for more intensive or novel therapy protocols [ 42].
Therefore, the question remains whether multigene assays can be used to (1) identify node-positive BC patients for who can safely be spared from undergoing chemotherapy and (2) tailor more intensive or novel drug-based treatment strategies in clinically high-risk cohorts.
The absence of effective therapies for advanced prostate cancer has entailed an intensive search for novel treatments.
Increased incidence of infections with multidrug-resistant bacterial strains warrants an intensive search for novel potential antimicrobial agents.
Besides the intensive research and novel developments in the catalyst field are a number of investigations conducted with reaction and separation engineering aspects at the TU Berlin.
Presumably, episodes of novel intensive selection pressures are not uncommon in nature [ 14, 15, 75].
Despite intensive research and novel adjuvant therapies, there is currently no cure for metastatic melanoma.
GAMEC is a novel intensive regimen for this group of patients producing encouraging responses, although with significant toxicity.
