Sentence examples similar to intensive hit from inspiring English sources

After intensive hit-to-lead optimization, compounds 17 (dual Aurora A and B), 21 (Aurora B selective) and 30 (Aurora A selective) possessed indazole privileged scaffold with different substituents, which provide sub-type kinase selectivity.

And what happened to all that intensive curveball hitting practice at the start of the season?

Here, the contact sheet proves how labour-intensive and hit-and-miss such an ambitious set-up could be – and, yes, the cats were repeatedly flung though the air by Halsman's assistants until he got the shot he wanted.

However, an HTS experiment often entails a very data-intensive and challenging hit prioritization process that yields the mentioned hit compounds.

This feeling lasted till I was checked again.' (Male, 21 years old, intensive phase, inpatient) 'It was time to be checked again.

Although preliminary health economic and QoL studies have been undertaken, further work is necessary, particularly in conjunction with clinical trials, to determine whether single 'one-hit' intensive HSCT-based treatments may prove cost-effective by preventing, delaying or otherwise limiting the need for biological and other treatments.

Indeed, the incidence of HIT in intensive care patients is about 1% [ 6, 10].

1-Cyclopropyl-4-{4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyri-din-2-yl}piperazine 1-Cyclopropyl-4-{4-[ 5-methyl-3-{3-[4- trifluoromethoxy phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-ylit after intensive medicinal chemistry optimization for potency and improved physicochemical properties (Fig.  1-Cyclopropyl-4-{4-[ 5-methyl-3-{3-[4- trifluoromethoxy phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl

Five people have been killed when a hospital in Gaza was shelled, hitting the intensive care unit, surgical and administrative areas, and an Israeli air strike has killed 28 members of the same family.

Research-intensive institutions would be hit most severely by increased competition from other countries as they recovered from the recession, he said.

It is certainly more labour intensive, but with unemployment hitting unsettling highs, a few more farmhands couldn't hurt society, could it?