We also point out that some potential applications of these models, such as phylogenetic reconstruction, would substantially benefit from using parameterizations that are less computationally intensive to fit than diGTR but succinctly capture the dominant effects.
More sophisticated and computationally intensive approaches for fitting the working model could be used, such as a proportional hazard model for interval-censored data, but we suspect that would not lead to a significant reduction in the bias, which is the major concern under a situation with dependent censoring for the WKM method.
Patients fitting for intensive FIr-B/FOx treatment, according to inclusion criteria, represented 44% of consecutively observed MCRC patients, and this rate was equivalent for fit young-elderly patients.
These statistical laws were developed to fit intensive measurement campaigns.
However, this probability is not very meaningful, as no strategy more intensive than FIT between 55 and 74 is analysed: the apparent confidence in cost-effectiveness is due to the omission of relevant alternatives rather than a high degree of certainty.
An intensive search of parameter space was performed, fitting from multiple starting points and restricting parameter bounds, to ensure that the best-fitting models were obtained.
The parabola fitting in Equation 9 contains a division, which is resource intensive when implemented in hardware.
qThe procedure is very computationally intensive because each time fitted values are required in the backfitting process, a posterior distribution must be approximated.
More specific large topics shared between the two corpora exist as well: topics 67 (labelled "information systems") and 88 ("large-scale analysis") are examples that seem to fit data intensive research fields.
It is clear that novel agents and new approaches must be used to improve the situation, and should include options for patients who are not fit for intensive treatment.
This latter point is significant because, as householders change their homes and daily lives to fit energy intensive consuming behaviours, it will become increasingly difficult to encourage people to reduce their household energy consumption.
