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The Futures Clinique begins with an intensive dose of Futures Provocation, a presentation introducing the basic concepts of futures thinking and futures research, the central ideas of the background paper and the answers received to the pre-questions.
In patients with advanced acute leukemia, the recovery of the granulocyte count (>500/μl) after an intensive dose of 5-AZA-CdR occurred at about day 45 [ 97].
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Arsen was born with hearing, his mother said, but lost it during a bout with meningitis and intensive doses of antibiotics when he was 2 years old.
These low dose schedules cause less toxicity than intensive doses of 5-AZA-CdR.
These observations illustrate the effectiveness of intensive doses of 5-AZA-CdR for tumor therapy.
Standard and intensive doses of statins are effective in reducing LDL-C levels [ 8].
The hematopoietic toxicity produced by intensive doses of 5-Aza-CdR can also be predicted from its comparative pharmacology with the related deoxycytidine analogue, ARA-C.
This is a clear indication that the resting normal hematopoietic stem cells survive intensive doses of S-phase specific agentS-phase specificover agentservadministeredrs) due tovere presence of resting non-proliferanintervaltofoietic stem cells [ 4].
These observations provide a rationale for intensive doses of 5-AZA-CdR in the range of 1,000 mg/m/day in leukemic patients in CR without encountering unacceptable hematologic toxicity for patients with a good performance status.
In the secondary prevention setting and high risk population, such as patients after ACS or stroke, we suggest, based on the current evidence, treatment with intensive doses of such a statin as atorvastatin 80 mg [ 27, 28].
Treatment protocols based on combination chemotherapy regimens designed for children, consisting of intensive doses of alkylating agents given in combination with methotrexate, vincristine, cytarabine, have been shown to be highly effective for patients with Burkitt's lymphoma, whether adults or children.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com