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That raises the question of how long natural populations can cope with high rates of change without extinction due to the negative effects on meiosis and before selection drives more intensive control of the underlying mechanisms.
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The recently reported increased mortality associated with intensive control of hyperglycemia in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial (3) has led to controversy about implementation of intensive glucose control in patients with type 2 diabetes.
Many studies on diabetes have demonstrated that an intensive control of glycaemia and the main associated risk factors (hypertension, dislipidaemia, obesity and smoking) reduce cardiovascular morbi-mortality.
Despite the importance of this health problem, there is a lack of definitive data on the effects of the intensive control of glycemia and other CVD risk factors on CVD event rates in patients with type 2 diabetes.
Despite intensive control of environmental factors in the modern propagation industry, high economic losses still occur as a result of insufficient rooting [ 1].
Numerous studies have demonstrated that intensive control of blood glucose reduces the development and progression of vascular complications in diabetes [ 1- 7].
With a limited area of BCs, larger contributing areas are favorable if no special emphasis is placed on the intensive control of peak flow reduction.
Several clinical trials, including Action to Control Cardiovascular Risk in Diabetes (ACCORD) [ 22], Action in Diabetes and Vascular Disease (ADVANCE) [ 23] and Veterans Affairs Diabetes Trial (VADT) [ 24], have shown that intensive control of glycemia does not consistently reduce the prevalence of cardiovascular events and, in some cases, may be harmful.
In the critically ill, intensive control of hyperglycemia with insulin results in decreased mortality and length of ICU stay.
Many studies have shown that the occurrence of these complications depends largely on the degree of glycemic control and intensive control of cardiovascular risk factors (CVRFs) (3– 5).
Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: A meta-analysis of randomized controlled trials.
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