Exact(4)
A brute force search is infeasible for epistasis detection in the genome-wide scale because of the intensive computational burden.
Another crucial challenge in two-locus association study is the intensive computational burden imposed by the enormous search space.
The first challenge is the intensive computational burden imposed by the enormous search space, which prohibits real applications of most existing methods, especially those exhaustive ones.
Most of them usually suffer from intensive computational burden induced by tuning extra parameters such as bootstrap size, and thus they are not computationally feasible at genome-wide scale.
Similar(56)
Metamodelling is an increasingly more popular approach for alleviating the computational burden associated with computationally intensive optimization/management problems in environmental and water resources systems.
To relieve the computational burden, metamodels are commonly used to replace the computation-intensive simulations.
Computing this factor z t results in heavy computational burden for normalization.
During the aircraft preliminary design phase, this clearance is done by intensive simulations, however, due to the involved models complexity, these latter are time consuming and imply an important computational burden.
Moreover, it increases computational burden.
The computational burden is thus significantly lower.
This might unnecessarily increase computational burden.
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