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Objective To determine whether intensive combinations of synthetic disease modifying drugs can achieve similar clinical benefits at lower costs to high cost biologics such as tumour necrosis factor inhibitors in patients with active rheumatoid arthritis resistant to initial methotrexate and other synthetic disease modifying drugs.
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Conclusions ADMIT demonstrates that it is both feasible and safe to modify multiple atherosclerotic disease risk factors effectively with intensive combination therapy in patients with PAD.
We used data from a published randomised controlled trial to assess whether responses to intensive combination treatments in early rheumatoid arthritis differ by ACPA status.
2015 Profile case Evaluation of treatment options N/A Meyfroidt S, Hulscher M, De Cock D, Van der Elst K, Joly J, Westhovens R, Verschueren P [56] A maximum difference scaling survey of barriers to intensive combination treatment strategies with glucocorticoids in early rheumatoid arthritis.
Fifteen patients with relapsed osteosarcoma were treated with an intensive combination chemotherapy schedule.
High values were observed in lymphocytes from patients with lymphoma during intensive combination chemotherapy.
These patients need a fast treatment response which can best be achieved by intensive combination therapy.
Moreover, intermittent gluco-corticoide treatment is often used as part of intensive combination treatment that may influence patients' views.
Better outcome for patients is the result of more intensive combination chemotherapies and improvements in supportive care.
2. Patients with potentially resectable metastasis that require intensive combination therapy to convert the disease to a resectable state.
In our study, intensive combination therapy was only needed to prevent radiological progression in ACPA-positive patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com