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The concentration of A i is an intensive variable: c i = N i / V, where V is volume.
More intensive LDL-C lowering was also associated with progressively greater risk reductions with higher baseline LDL-C level for myocardial infarction, revascularization, and MACE.
The effects of intensive LDL-C lowering on neurocognition might be attributed to an off-target effect.
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Improved screening for diabetes and reducing the prevalence of undiagnosed diabetes may identify individuals requiring more intensive LDL-C reduction.
Intensive LDL-C reduction has been reported to achieve greater regression, but this study did not include an early time point [7].
More recently, intravascular ultrasound (IVUS) of the coronary arteries has demonstrated coronary plaque regression following intensive LDL-C reduction in over 300 patients treated with 40 mg rosuvastatin for 2 years [5].
This subanalysis of the COSMOS study was a post-marketing study designed to investigate the effects of intensive LDL-C lowering with rosuvastatin on coronary atherosclerosis measured using IVUS and its safety; as such, the lack of glucose measurements and the small sample size limit further interpretations of the current results.
(b) Thermo-mechanical ablative, as highly intensive focused US. (c) Electro-ablative, as irreversible electroporation.
