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While there have been other fabrication intensive approaches for 3-dimensional focusing, this approach is relatively straightforward and easy to fabricate.
More sophisticated and computationally intensive approaches for fitting the working model could be used, such as a proportional hazard model for interval-censored data, but we suspect that would not lead to a significant reduction in the bias, which is the major concern under a situation with dependent censoring for the WKM method.
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Baseline participant report of neuropathy/nerve problems defined a subgroup in which the intensive approach for glycemia treatment had a differential effect on mortality, with a highly significant P value of 0.0008.
While EMSA was used here for selecting thresholds, there could be other, less labor-intensive approaches, for example fluorescence correlation spectroscopy (FCS) [ 51].
Today, computer-intensive approaches for parameter inference, such as Bayesian Markov chain Monte Carlo (Sorensen & Gianola 2002; Gelman et al. 2004) or approximate Bayesian computation (Beaumont et al. 2002), can be implemented effectively in today′s high throughput systems (Wu et al. 2011).
patients selected for intensive approaches (group 3) were younger and had higher risk disease features (higher normalised serum LDH, B symptoms).
Less resource intensive approaches are perhaps adequate for individuals with lower baseline BMI in the overweight and obesity continuum, whereas the incremental benefit of more intensive, structured lifestyle change programs may not be evident except for those with higher BMI indicative of moderate or severe obesity.
19 Key interventions assessed were standard and intensive approaches to glycaemic control, screening for retinopathy and subsequent treatment as needed, and screening for neuropathy plus associated preventive foot care (appendix 4 on bmj.com provides a more detailed description of these interventions and how they were modelled).
And while it was disappointing that we were unable to show any improvement in outlook despite the current more general use of intensive approaches to cardiovascular risk reduction for patients with diabetes (4), this may have occurred too recently to have had an impact on our data.
International guidelines recommend intensive multidisciplinary approaches for patients with cLBP.
The need for the highest activity coupled with major chances of disease control make such an intensive approach especially suitable for the conversion setting of potentially resectable CRC metastatic to the liver.
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