Plantar-palmar erythrodysesthesia, an epithelial toxicity observed in patients receiving protracted infusions or repeated dose-intensive administration of doxorubicin (Samuels et al, 1987; Bronchud et al, 1989), and the dose-limiting side-effect of caelyxs™ (Ranson et al, 1997), was not observed with DaunoXome in this study.
Paradoxically, because of more prolonged time and less intensive administration, the number of CMF cycles fared better among patients who received concomitant radiotherapy.
The patients were randomly assigned to an active treatment or a placebo group and received intensive oral administration of Artemisia pollen extract over a 50-day course.
Accurate prediction of pre-eclampsia is important, because intensive monitoring and administration of early treatment with e.g. aspirin [ 29] can be more selectively targeted at high-risk women, making timely intervention easier and possibly more cost-effective.
The DCCT study showed that intensive insulin therapy (administration of insulin three or more times daily by injection or an external pump) decreased the frequency and severity of microvascular and neurologic complications compared to conventional insulin (DCCT 1993).
In order to treat the disease and prevent the patient's body from rejecting the transplanted cells, patients undergo intensive conditioning, which involves administration of chemotherapy and radiation.
This indicates that administration of intensive consolidation courses is more problematic in patients older than 45 years.
This case of CA-MRSA ST30 infection in a child represents a progression from common cold like symptoms (occurring outside the influenza season) to fatal pneumonia, despite intensive therapy, including the administration of sensitive antimicrobial agents.
Approximately 3 weeks after the final induction treatment, patients were admitted for administration of intensive, high-dose chemotherapy (HDCT) consisting of cyclophosphamide (6 g m−2), mitoxantrone (64 mg m−2) and vinorelbine (95 mg m−2) over 4 days.
In order to treat the disease and prevent the patient's body from rejecting the transplanted cells, patients undergo intensive conditioning, which involves the administration of chemotherapy and radiation.
