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Intensive activation of glial cells is a prominent feature in both patients' brain metastasis tissues and animal models of the disease [ 34].
More importantly PEE exposure could provoke intensive activation of ER stress which might be the cardinal apoptotic mechanism of PEE-induced inhibition of bladder cancer cell.
Consistent with the intensive activation of caspase-3 and caspase-9 after the combination treatment, Annexin V/propidium iodide staining of AGS and MGC80-3 cells indicated an upregulated proportion of cells proceeding through apoptosis.
Because our previous study demonstrated an intensive activation of Cdc42 specifically within the spine head following single spine glutamate uncaging stimuli (Murakoshi et al., 2011), we expected that Cdc42 cKO neurons may show specific defects in activity-dependent spine enlargement.
Besides we found that PEE exposure to T24 cells could provoke intensive activation of procaspase-12 and enhance the expressions of CHOP and Bip, endoplasmic reticulum (ER) stress marker, suggesting that ER stress might be the cardinal apoptotic mechanism of PEE-induced inhibition of bladder cancer cell.
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The free-standing geometry and well-aligned textures of graphene monolith are persevered even after an intensive KOH activation at 973 K, although the frame structure is slightly disordered.
The intensive immune activation observed both in measles patients and infected CD150 transgenic mice may need to be controlled by Treg cells to avoid tissue damage.
Vasculitis can trigger aHUS by intensive complement activation or by endothelial damage in a patient with a genetic predisposition [ 10].
In the histopathologic examination of liver, the presence of cytomegalic cells and inclusion bodies refers to the intensive immune activation against viral attack.
Low amounts of PMP are continuously shed from platelets, but this process is highly accelerated after platelet activation or intensive physical activity.
The hyper-regulated state, on the other hand, was perturbed by an "inflammatory burst" (a short, but intensive upregulation of APC activation), which roughly corresponds to a spontaneous immune reaction against a self-antigen.
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