GO and SSu extracted data independently for each included paper onto a piloted form including: year and study location; recruitment method; participant flow; risk of bias; participant, intervention, and comparator characteristics; frequency and intensity of outcome measurement; and data on self reported and objective physical activity, cardiorespiratory fitness, and adverse events.
Finally, Leathers and Olson (2012) found that lateral intraparietal area (LIP) neurons fired in proportion to the intensity of predicted outcomes, regardless of valence.
Each clustering/cluster detection method has its own strengths and weaknesses and may not be appropriate to all datasets because each dataset differs in spatial resolution (point or areal), spatial coverage (area covered by dataset) and spatial intensity (distribution of outcome of interest) (Fritz et al. 2013; Waller and Gotway 2004).
Overall, it was not possible to conduct a meta-analysis as the studies varied widely in terms of approaches, types, duration and intensity of interventions and outcomes reported.
Studies found no significant difference in outcomes between residential and outpatient treatment and no clear relationship between intensity of treatment and outcome (Fink et al. 1985; Longabaugh et al. 1983; McCrady 1986).
One of our study strengths was to include a control group of youngest patients, i.e., octogenarians, to analyze comparatively the intensity of treatment and outcome.
In multivariate analysis with gender and conditioning intensity as predictors of outcome, female gender remained a borderline significant predictor of longer RFS, independent of the conditioning intensity (HR=0.30, 95% CI: 0.09 1.07, P=0.06).
Jette DU, Warren RL, Wirtalla C. The relation between therapy intensity and outcomes of rehabilitation in skilled nursing facilities.
In addition, directions for future research are identified, including study design, methods of defining and measuring treatment intensity, and selection of outcome measures in aphasia rehabilitation.
Investigators commonly use NRS's of pain intensity as outcomes in clinical trials of pain therapies, and these ratings have been demonstrated to be valid, reliable, and sensitive to detecting change in pain intensity after treatment [ 20].
