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In recent years, the question has been raised as to whether or not the type of statin and the intensity of dose contributes to the conflicting results observed in RCTs and meta-analyses.
The median cumulative dose of cetuximab was 4659.4 mg/m and the median intensity of dose per cycle was 447.1 mg/m; therefore the median cetuximab dose used in this study was similar to the recommended 500 mg/m dose.
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The median relative dose intensity of pomalidomide (dose intensity/planned dose intensity) was 1.0 and 0.89 for patients in Cohorts 1 and 2, respectively.
The variable DOSFREQ refers to the frequency (intensity) of dosing, which we define as the number of 'unit administrations' in a given year.
The interaction term DOSFREQ.INDICATN is intended to capture the notion that treatments for acute illnesses tend to have less 'complex' dosing regimens compared to those for chronic illnesses; and the quadratic term DOSFREQ2 is intended to determine whether the marginal effects of DOSFREQ are increasing or diminishing as the frequency (intensity) of dosing increases.
One example was intensity of the "dose" of SPI1 given to the wards.
Neither study showed a benefit in outcomes by increases in intensity of RRT dose.
Trabectedin neutropenia seems to be largely dependent on the intensity of the dose, but not the duration of infusion.
However we have not analyzed if electrolytes disorders were associated to the intensity of fluid dose prescriptions.
The median dose intensities (ratio of dose received to dose planned) of 5-FU, capecitabine, oxaliplatin and bevacizumab were ⩾0.89 in all treatment arms.
The relative dose intensity of planned epirubicin doses was 89.1% with FEC100 and 88.9% with Epi-Vnr.
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CEO of Professional Science Editing for Scientists @ prosciediting.com