Main outcome measures were headache frequency, duration, intensity, medication consumption and days of absence from school.
One-way analysis of variance (ANOVA) was applied to the comparison of the age, BMI, education, migraine duration, headache frequency, pain intensity, medication intake, HAMA, HAMD, MMSE, and MoCA score.
Patients were asked for their concurrent medical diseases, type of migraine, migraine chronicity, age at onset, duration of migraine, headache intensity, medication overuse headache, family history of migraine, accompanying symptoms including nausea and/or vomiting, photophobia, phonophobia, osmophobia, and allodynia.
CBT + Relaxation RCT Sorbi, 2015 [48] N = 368 (18 65) HA centers, website, + flyers 8 weeks* Migraine with 2 6 attacks in the month prior to randomization HA index; HA intensity; Medication; Self-efficacy; QoL; Disability; LoC; Other NS in HA frequency or intensity in either group or between groups.
Reduction in headache frequency, headache pain intensity, medication intake, absenteeism and looking for professional help will be used as secondary outcome measures.
Reduction in headache frequency, pain intensity, medication intake, absenteeism and headache related health care contacts were secondary outcome measures and were collected via a questionnaire.
The studies used varied headache related outcome measures: headache index, headache duration, headache frequency, headache intensity, medications, self-efficacy, quality of life, sleep, anxiety, depression, distress, and disability.
The 2010 European League Against Rheumatism (EULAR) recommendations stated that 'patients with a favourable prognosis very often respond similarly to low-intensity monotherapy or intensive medication strategiesʼ, suggesting that for patients with a poor prognosis this might be different [ 8].
If possible, the evaluation of long-term outcome of patient with MOH should be based on headache diary information preferentially including data on headache days/month, headache intensity and medication days/month.
PI, pain intensity The medication pattern shifted from sedative to analgesic infusions.
