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Frequency of migraine, headache intensity, days with use of pain medication and triptans were significantly reduced during TP2 in comparison with BL (Table 2).
This analysis showed significant decreases in headache number, intensity, days, and number and percent medicated headaches in the diet group (all p<0.05, Table 5).
Numbers of monthly migraine days, headache days, headache intensity, days with use of pain medication and questions of the MIDAS questionnaire were compared with Friedman's test.
We considered alternative definitions of a heat wave based on six different combinations of intensity (days with daily mean temperatures ≥ 97th, ≥ 98th, or ≥ 99th percentile) and duration (≥ 2 or ≥ 3 consecutive days of high temperatures).
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In the intention-to-treat analysis, withdrawal headache intensity decreased significantly after withdrawal with significant differences among the three groups (headache intensity, days-effect: p < 0.001, F = 10.00; group effect: p = 0.002, F = 6.17).
Withdrawal headache intensity decreased significantly after withdrawal without differences among the three groups (headache intensity, days-effect: p < 0.001, F = 13.25; group effect: p = 0.103, F = 2.30; interaction days-group effects: p = 0.192, F = 1.41) (Table 2).
According to the intention-to-treat analysis, withdrawal headache intensity decreased significantly after withdrawal with significant differences among the three groups (headache intensity, days-effect: p < 0.001, F = 10.00; group effect: p = 0.002, F = 6.17) without differences when considering their interaction (headache intensity, interaction days-group effects: p = 0.508, F = 0.91).
Overall-pain was the average pain intensity among days in pain and peak-pain was the maximal single-day pain intensity.
The headache intensity on days with headaches was unchanged in all three groups.
hVariable Ns reflect the fact that participants with incomplete headache diary data were excluded from analysis of headache number, intensity, duration, days, and/or medication rates as appropriate.
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