The peak was barely detectable upon addition of NADH but intensified upon addition of an electron acceptor.
Previous solution NMR studies have demonstrated weak, transient interdomain interactions for apo Pin1 that intensify upon addition of phosphopeptide substrate.
In the present study, as the first MM, sixth, and seventh ALLs were less intensified upon activation in fibers from the older individuals, we suggest that the mean orientation of the myosin heads bound to actin monomers gets more disordered during contraction, inducing an incomplete actin monomer activation and abnormal cross-bridge formation.
Irradiation caused only a slight increase in the G2/M cell cycle population, but this effect was intensified upon ATM inhibition, suggesting that the efficient DDR prevented a more pronounced effect on cell cycle progression of irradiated MRC-5 cells (Supplementary Figures S2a d).
The observation at the transcription level was faithfully imitated at the protein level, where both enhancement of CK2 activity and CK2 overexpression reduced the protein expression of p27 Kip1 and Bim, while the protein levels were intensified upon CK2 inhibition and PML overexpression, respectively.
How long the rupture will last and whether it intensifies will depend upon the response of Russia's president, Vladimir Putin and above all on whether he steps back from escalating the bloody insurrection in eastern Ukraine that he has encouraged.
But they intensified last week upon word of a new threat.
While the President was away, the fighting in Vietnam intensified, and upon his return from his European tour he was asked at a press conference whether the United States would renew the bombing of North Vietnam.
As freight flows through global supply chains intensify, dependence upon maritime transportation increases.
For simplicity, only two bands (denoted by arrowheads), which were protected (A ) or intensified (B ) upon TFIID binding, were selected for quantification (right).
