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Continuing decline of beta-cell function means that the initial choice of OAD (typically metformin) frequently proves unable to provide adequate glycaemic control, so treatment intensification is required.
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There is also evidence indicating that FPs/GPs are challenged when intensification of medication is required [ 7, 13].
The indigenous cattle and the prevailing extensive rural production system are unlikely to be able to satisfy the rise in demand for animal products, therefore intensification of animal husbandry is required.
Over two-thirds of patients in the 4-T study needed more than one type of insulin to achieve target HbA1c suggesting that once insulin is initiated, monitoring and intensification of insulin therapy is required [ 13].
A treatment to achieve tighter glycaemic control, and overcome the barriers to insulin initiation and intensification, while providing activity beyond 24 h, is required.
The quest for spiritual intensification is elitist even when, as within Christian monastic orders, humility is required.
Intensification of cavitational activity and efficient design of industrial scale hydrodynamic cavitation reactors is required for ensuring successful application of cavitational reactors at industrial scale operation.
However, initiation and intensification of insulin therapy can be demanding for patients and health care practitioners because daily blood glucose monitoring is required.
Interventions that provide decision support to patients and clinicians regarding medication intensification may be required to improve clinical metrics.
IFX-intensification treatment, however, was required by 70.8% of UC patients.
In these patients an intensification of antirheumatic therapy was required to treat the deterioration of SAPHO syndrome activity.
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