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To test the hypothesis, mice were exposed to moderate or intense sound levels either concurrently or prior to gentamicin treatment.
Juvenile C57Bl/6 mice were exposed to moderate or intense sound levels, while fluorescently-conjugated or native gentamicin was administered concurrently or following sound exposure.
This method is based on the fact that a human listener perceives note onsets as more intense if they occur after a longer time of lower sound level and thus are not affected by temporal post-masking caused by previous sounds [33].
Conditioning is the phenomenon where exposure to moderate-level acoustic stimuli can increase the ear's resistance to subsequent more intense sound exposures.
SOUND LEVEL Pleasantly quiet.
SOUND LEVEL Conversational.
SOUND LEVEL Rollicking.
SOUND LEVEL Under control.
SOUND LEVEL Say that again?
SOUND LEVEL Very, very loud.
SOUND LEVEL Relatively quiet.
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