The involvement of local protection committees is paramount for intense community sensitization activities to facilitate the change process of social norms.
A plausible explanation for our patients' remarkable response to rizatriptan is that intense trigeminal peripheral afferent activation or sensitization in migraine patients with UAs strongly recruits peripheral neurovascular 5-HT1B/1D recepthose targetedrgeted by triptans.
Experimental studies in animals [29] and humans [30] show that SSEP amplitudes increase when transient intense activation of nociceptive afferents induces central sensitization, as happens in clinical pain conditions including chronic headache.
It also sheds light on inflammatory pain sensitization, which causes patients to feel intense pain even in response to normally innocuous stimuli, such as a light touch.
Preliminary results show that the dendron-functionalized carbazole units not only tune the carrier-transporting capability, but also exhibit strong light-harvesting potential, resulting in a strong intense emission from the central Eu III) ion via sensitization.
The driving factors and molecular mechanisms involved in sensitization are still unknown even though intense research efforts have been carried out to characterize the immunological responses towards allergenic chemicals.
Lung cells from HDM-pulsed BMDC-sensitized C3H mice produced both Th2 (IL-4, IL-5, IL-13) and Th1 (IFNγ) cytokines (Figure 8c), similar to the pattern observed following sensitization with HDM, albeit ∼10-fold more intense (compare to Figure 1d).
A trend observed from the seven-week post infection/sensitization time-point indicated that the M. bovis sensitized cattle demonstrated a more intense antibody response and to additional M. bovis Ags, especially MPB70, MPB64 and MPB64/MPB83, as compared to the M. bovis infected cattle.
Continuous and intense nociceptive input from the OA knee joint may drive central sensitization, which may arise from chronic nociceptor stimulation and subsequent modification of central pain-transmitting neurons, and may be clinically associated with NP qualities [ 1, 2].
Carbide precipitation due to a welding process or heat treatment can cause the occurrence of chromium-depleted zones at the grain boundaries, leading to a phenomenon known as sensitization, in which the depleted zones become the focus of the intense corrosion [3, 4].
