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In practice, the target lesion on baseline scan was chosen as the most intense lesion and located by scaling the 3D MIP view both on the OSEM and PSF ± TOF reconstructions.
The same VOI methodology was used on the post-treatment scan, where the target lesion was chosen as the most intense lesion for PERCIST, while the same target lesion for baseline and post-treatment scans was used for EORTC classification.
For example, for patients demonstrating intense lesion uptake (P3, P8), AD was estimated to be approximately 8.5 and 11.5 Gy, respectively, when their livers would receive 3.8 and 11.1 Gy.
A PMR was defined as more than a 30% and a 0.8-unit decrease in SULpeak between the most intense lesion before treatment and the most intense lesion after treatment, although not necessarily the same lesion.
The reported SUV or Kpat values are the measurements from the most intense lesion identified on the patient's first FLT-PET scan.
Similar(55)
64% (34/53) of FDG intense lesions were observed in the same location for both PET-CT and PET-MRI.
They presented as round hyper intense lesions measuring up to 5.0 mm in diameter.
Animal no. 2 displayed more intense lesions, with numerous admixed eosinophils within leptomeningeal and perivascular infiltrates.
For very intense lesions, spillover of activity into adjacent voxels can make them appear larger than they are.
They observed decreasing GLD particularly for shorter exposed or less intense lesions in direct comparison of 1 hour and 6 month OCT images [ 41].
Importantly, baseline tumor SUV strongly determines the variability in %-change in SUV over time: less intense lesions at baseline show greater spurious %-change.
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