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In our study we supplied gemcitabine and vinorelbine as dose intense induction chemotherapy in a short time interval of two weeks, in order to kill malignant cells in existing micro-metastases and to reduce the planning target volume (PTV).
A Spanish study (Calvo et al, 2003) explored a short, intense induction regimen of oxaliplatin and 5FU (FOLFOX 4) before conventional CRT, which appeared to improve the tumour downstaging when compared to historical results in their unit previously achieved with CRT alone.
The mechanisms explaining the different spectrum of lymphoma subtypes among transplant patients compared with the general population include immunosuppression, including the early, intense induction phase and the later maintenance phase; chronic immune activation because of the presence of donor organ tissue; or the combined effects of these, resulting in long-term, chronic immune dysfunction.
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Heat-shock proteins (HSPs) are cellular mechanisms which react to any intense stress induction (Roberts et al. 2010).
Yet, we were still able to demonstrate differences or tendencies in lung responses in these small numbers of animals that had undergone an intense allergy induction protocol.
In conclusion, using an intense allergy induction protocol in pigs, we demonstrated that Lactobacillus rhamnosus HN001 supplementation reduced the severity of allergic lung outcomes and was accompanied by a tendency of increased Th1 (IFN-γ) responses balanced with increased regulatory responses (IL-10 production) to the allergen.
The higher the T cells' TMs, the more intense the induction of DNA-PKcs transcription.
Pneumocystis jirovecii pneumonia (PJP) is a dreaded complication of immunosuppression and has been shown to occur most frequently in patients undergoing intense remission induction therapy [ 88].
Thus, the true excess of Irga6-1A in the high expression patches relative to the general parenchyma was 100 × 27.9/5.9 or about 470×, confirming the intense local induction by IFN-γ.
Successful outcomes have been reported in recurrent T-LBL using intense re-induction chemotherapy followed by either autologous (auto-) or allogeneic stem cell transplant (allo-SCT), but these series each contained 10 or fewer T-LBL patients, so reliable survival figures are not available.
The philosophy behind the intense 2-month induction is that EMBL "believes Ph.D.s institute a lot of collaborations," according to Anton.
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CEO of Professional Science Editing for Scientists @ prosciediting.com