These conditions cannot be resourced in mainstream state schools because of large class sizes and intense curriculum constraints.
The question, for some, is whether the chances of adding drug benefits to Medicare will be much better next year, when Congress could be confronting the brutal combination of a recession, intense budgetary constraints and the pressures of an imminent election.
The heartbreaking scene where Mrs. Hughes comes in and finds Anna after the attack was one of the few scenes on the show where you have two characters really breaking past the intense social constraints of the time.
However, in doing this with tRNAs we must be very careful, as these molecules violate the assumptions of these conventional methods – owing to their small size and intense functional constraint.
Although TLRs have been regarded for a long time as a classic example of strong evolutionary conservation and intense functional constraint [ 3, 4], a recent comparison of several Drosophila genomes showed for the first time the fast evolution between closely related species [ 5].
Once again the Welsh NHS is under intense pressure: financial constraints continue to be acute and many targets missed throughout the year.
It is under intense pressure, with financial constraints continuing to be acute and many key targets missed throughout the year.
It is important to recognize that we focused on epitopes known from prior work to be subject to rapid escape; other CD8+ T-lymphocyte epitopes within these same individuals showed more gradual escape [9], [3], [4], [5] and may be under greater fitness constraints, less intense immune selective pressures, or both (Ferrari, et al. 2010, submitted).
Many providers felt highly anxious and frustrated by having to manage competing and intense pressures within the constraints of limited resources, further fueling a sense of marginalisation from the present context: I lie awake at night, worrying that I will be sued, my house and car repossessed, my family compromised by these challenges.
