A randomised phase 2 study containing 89 patients compared standard CapOx (Cap1000 mg/m2/BD d1-14 q21d; Ox130 mg/m2 d1 q21d) with dose intense CapOx (Cap 1750 mg/m2/BD d1-7, Ox85 mg/m2/d1; q14d) and reported a higher confirmed radiological response rate (54.5% v 42.2%) and longer PFS (10.5 v 6.0 months, p = 0.0013) favouring the dose intense schedule.
At this time point, a DAPI-intense cap-like structure is noticed at the apical site of the nuclei that moves towards the implantation fossa of the tail which often can be observed during nucleus elongation and condensation (the tail is usually lost in the spreading procedure) (Fig. 2A).
The intense exchanged capped a debate in which the Democratic presidential hopefuls forcefully appealed for the support of organized labor.
Saturday's agreement was the product of years of preparation, two weeks of intense negotiations, capped off by three sleepless nights, with Barack Obama and Hollande phoning other leaders to bring them on side with the deal.
Saturday's agreement was the product of years of preparation and two weeks of intense negotiations, capped off by three sleepless nights, with Barack Obama and Hollande phoning other leaders to bring them on side with the deal.
On Thursday, the chancellor had bowed to intense pressure to cap tax relief on charitable donations – his third budget about-face in less than a week.
Spinning in the post, crashing the boards for rebounds and wearing his usual intense stare, Hansbrough capped a career that will rank among the university's best.
Saha's international career never really took off — injuries were a regular issue and, even when fit, competition for places was intense — but 20 caps and four goals for France over an eight-year period meant far more than playing for England could ever have done.
The release of the Lebanese citizens capped intense diplomatic efforts among Lebanese, Syrian and Turkish authorities and the reported mediation of the foreign ministry of Qatar, which, like Turkey, has long been a crucial backer of anti-government forces in Syria.
The layered lemon tartlette ($7) with whipped cream beneath its phyllo crisp cap is intense, tart and terrific.
