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"I don't think it's an intended difference, but it highlights financial things like not being able to throw money at the problem and solve it very quickly".
Some chemical contaminants would almost certainly get into the diets of the 'organic' group despite the very best efforts to prevent it, and these would also contaminate the study- because they would narrow the intended difference between treatment groups.
On the other hand, the study also failed to achieve the intended difference for postprandial hyperglycemia by far, so the negative result over a 4-year follow-up may not be a total surprise.
The prevalence of ankle sprain recurrences being about 13% in 12 months [ 11], 275 subjects per group were needed to detect the intended difference of 50% in the incidence of acute ankle sprain recurrences, with a power of 80% and an alpha of 5%.
12 With a prevalence of recurrent ankle sprain of 13% in one year, 9 we needed 275 people per group to detect the intended difference of 50% in the incidence of recurrences, with a power of 80% and an α of 5%.
The prevalence of lower extremity injuries in basketball in Flanders being about 78% in one season [ 6], 34 subjects per group are needed to detect the intended difference of 50% in the incidence of lower extremity injuries, with a power of 90% and an alpha of 5%.
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Although not intended, the difference between the two groups may mean that controls had more access to dietary information, enabling them to eat healthier, and possibly consume food types with higher selenium content.
Despite that the participants themselves reported the program as being well suited and that it had improved their skills as intended, no difference between the groups in terms of recognition of depression or improvement in depression scores among the patients with known depression was found after six months [ 17].
Although no formal comparisons were intended and differences were small, NEPA300 had numerically higher response rates than the multiday APR regimen for all the efficacy endpoints and time intervals.
On stage, the instrument may look exactly like a standard concert grand, but under the lid things are very different, the differences intended, it seems, to combine the power and projection of a modern instrument with the range of colour and touch that can be obtained from 19th-century instruments.
The government opened a two-month reconciliation convention in Abidjan intended to settle differences among the country's main political parties and put an end to two years of chronic instability.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com