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However, with regard to Gene Ontology categories there is some concordance between their and our results: age-repressed genes were over-represented in categories involved in genomic integrity, regulation of transcription and chromatin remodeling [33], [34].
Such mechanisms are critical for maintenance of genome integrity, regulation of transcription, and organization of chromatin into higher-order structures.
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The wide-ranging role of vitamin D in musculoskeletal health, epithelial barrier site integrity, and regulation of both innate as well as adaptive immunity, in addition to calcium homeostasis, may explain how optimizing 25OHD levels in critically ill patients may improve outcomes [40].
Especially genes involved in genomic integrity and regulation of transcription were age-repressed.
MoSec22 participates in the maintenance of cell wall integrity and regulation of ROS levels.
This concept is compatible with our observation that genes involved in genomic integrity and regulation of transcription are age-repressed.
Nucleosome survival during transcription is important for the maintenance of chromatin integrity, gene regulation, cell survival, and aging.
We characterized the Δstn mutant and showed that Stn might affect membrane integrity via regulation of OmpA localization.
This strongly suggests a role for SP in maintaining bone integrity and regulation of bone formation and bone resorption.
The main theories of PC-induced protection are the preservation of mitochondrial integrity via regulation of the mitochondrial permeability transition pore (mPTP) [ 2].
Insertion sequence (IS) mapping has also demonstrated the role of IS 6110 as a major driver in mycobacterial evolution by affecting gene integrity and regulation.
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