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As the integrity of the barriers is crucial for immune cell recruitment, we examined the functional status of the barriers with a fluorescent tracer, NaFlu.
Irritation of the skin from any cause or irritation of the throat by habitual smoking of tobacco impairs the integrity of these barriers and predisposes the area to invasion by potentially harmful organisms.
Disturbance of cerebral hemodynamics due to destroyed integrity of endothelial barriers also contributes to brain damage [ 22, 32].
A leakage or an alteration in the turnover of brain-derived proteins may be used to evaluate the integrity of these barriers, possibly reflecting an effect of RF.
Advancing age is closely related to weakened integrity of physical barriers as well as low immune responsiveness against invading pathogens because of respiratory tract immunosenescence [ 25].
Both proteins localize at SJs, show interdependence for localization and restricted mobility with known SJ members and are required for the integrity of epithelial barriers.
Compromising the integrity of this barrier can promote manifestation of enteric infections and is a key feature of IBDs like Crohn's disease (CD) and ulcerative colitis (UC).
The overproduction of nitric oxide by PMN could be one of the factors compromising the integrity of mucosal barrier, by directly increasing its permeability and bacterial translocation [49], [50].
The integrity of endothelial barrier is important for the maintenance of normal endothelial structure and function.
Thus, elevated albumin in urine indicates damage of the integrity of the barrier.
This inflammatory reaction can itself impact on the integrity of the barrier function.
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