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This chapter provides an overview of how the DDR operates within the chromatin landscape to maintain genome and epigenome integrity, functions critical for cellular homeostasis and averting diseases including cancer.
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Chromatin integrity is critical for cell function and identity but is challenged by DNA damage.
Biomechanical integrity is critical for healthy functioning of the joints.
As preservation of endothelial integrity is critical to normal vascular function, we also evaluated the effects of TA on human umbilical cord endothelial cells (HUVEC).
DNA integrity is critical for proper cellular function and proliferation in AML.
Vascular EC barrier integrity is critical to tissue and organ function [ 1, 25].
Thus, BBB integrity is critical to ensure optimal CNS function and its disruption during cerebrovascular pathologies can be prodromal to the onset and progression of major neurological disorders [ 6].
Genes involved in DNA repair and ribosomal function may contribute to OS pathogenesis, because they maintain the integrity of critical cellular processes.
Therefore, ensuring spatial query integrity is critical.
Rotator cuff integrity is critical to shoulder health.
The Maintenance of Genome Integrity (chromosome number and integrity) is critical to prevent cell inviability, inherited disorders, and disease.
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