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The results from fluorescence spectroscopy and transmission electron microscopy (TEM) suggested that Py11 kills bacterial cells possibly by integrity disruption damaging the cell membrane, leading to the cytosol leakage and eventual cell lysis.
Longer incubation times were not investigated to avoid any possible cell membrane integrity disruption due to low pH.
Interstitial brain edema and white matter integrity disruption occurring in HD ESRD patients may account for the cognitive deficits in ESRD patients.
We found that inflammation was significantly induced, without influencing cardiac cell viability and size (Supplementary information, Figure S2 and S3) or cardiac tissue integrity disruption (Supplementary information, Figure S4).
A longitudinal MRI study in individuals with advanced age suggested that accumulating white-matter changes in advanced age are probably driven by small-vessel ischemic disease, and even suggested there might be a link between AD pathology and white-matter integrity disruption [ 83].
In the case of fulleropyrrolidine treatment, a high level of cell envelope integrity disruption has been reported in response to activation with light, indicating that this compound binds to the cell envelope and exerts its bactericidal activity in close proximity (Grinholc et al. 2015).
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An evaluation of the central subfield retinal thickness (CST), the integrity or disruption of the interdigitation zone), the integrity or disruption of the EPIS), and the integrity or disruption of the interdigitation zone and the EPIS together) was performed.
Loss of synapse and axon integrity and disruption of axon transport characterize many neurodegenerative diseases.
In addition, oxidative stress has been shown to have an injurious role in BRB integrity by disruption of tight junctions in retina [60].
The skin barrier is crucial in maintaining skin integrity, and disruption of the epidermal barrier is one of the important mechanisms in the pathogenesis of eczema [ 21, 22].
Tumour endothelium is dependent on its microtubule cytoskeleton for structural and functional integrity, and disruption of microtubules can trigger a series of changes that shutdown blood flow in the tumour microvasculature (Hinnen and Eskens, 2007).
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