We would think this person's integrity diminished by their failure to make a serious attempt to see the project through, yet the writing of a novel need not be a moral project.
Not surprisingly, lysosomal integrity diminished with increasing toxicity (3 10 μM), suggesting that celastrol's effects indirectly overburden lysosomal degradative pathways, thereby interfering with autophagy-mediated degradation.
Conversely, protection of mitochondrial integrity diminished I-BET762 antitumoral activity, thus demonstrating the importance of mitochondrial damage as a key event in I-BET762-mediated apoptosis.
Its findings are grim the commissioners write that the failure to properly manage the nation's coasts and oceans is "compromising [these resources'] ecological integrity, diminishing our ability to fully realize their potential, costing us jobs and revenue, threatening human health, and putting our future at risk".
It was revealed that tight control of the alloy's temperature within a narrow range around the liquidus level generated structures with high integrity and diminished some disadvantages inherent for conventional casting which utilizes superheated melts.
KOH activation is a well-accepted approach to develop microporosity for porous carbons, but its severe etching reactions could inevitably destroy the structural integrity and diminish the heteroatomic surface chemistry of the resultant carbons.
These results suggest that NEFH is needed for maintaining normal cell integrity and diminished NEFH levels are seen in common cancers.
In addition, loss of islet integrity could diminish the β-cell incretin response.
The removal of these aromatic side chains are expected to perturb the hydrophobic core, and the loss of structural integrity in turn diminishes the inhibitory activities against cathepsin B. This is particularly pronounced for W9A, lending support to the importance of these aromatic residues in protein folding.
When judges "personally ask for money", their integrity may be diminished in the eyes of the public.This sounds sensible, but the dissenters have a point when they complain that this version of strict scrutiny is rather weak tea.
