RNA integrity is a critical determinant of sensitivity in RT-PCR SARS-CoV assays.
Since both the expression/activation of degradative enzymes and the number of chondrocytes committed to cell death are important determinants of cartilage integrity, our results suggest a pivotal role for the PKR pathway in arthritic disease onset and progression that requires further investigation.
It is well established that a river's natural flow regime is a key determinant of ecological integrity and that dam regulated-flow releases can be detrimental to biotic communities and even affect river ecosystem structure (e.g. Poff and Zimmerman, 2010).
The positively selected residues 215, 217 and 226 fall within a region thought to be immunogenic of neutralising antibodies [71], [72], and residue 297 has previously been identified as a determinant of the integrity of multiple overlapping strain-specific epitopes [73].
Taken together, these data identify ROS as a potentially important determinant of lysosomal integrity and an effector of phenothiazine-mediated chemosensitization.
Another important determinant of genomic integrity and cellular response to DNA damage is the level of intracellular reactive oxygen species (ROS), which is tightly regulated through the coordinated activities of cellular pro-oxidants and antioxidants.
We have recently shown that the histone methyltransferase SETD2 (also termed KMT3 or HYPB), which is responsible for all H3K36 trimethylation, but not H3K36 mono- or dimethylation (Edmunds et al., 2008), acts as a determinant of chromatin integrity by regulating nucleosome dynamics during transcription (Carvalho et al., 2013).
MicroRNAs (miRNAs), a class of non-coding RNAs, have been identified as important determinants of the functional integrity of pancreatic beta-cells.
The healthy myocardium contains an ECM that is a major determinant of its structural integrity and mechanical functions [3].
In particular, the three-dimensional (3D) collagen fiber arrangement is important as it is the key structural determinant that provides mechanical integrity and biological function.
