Significantly, these sites directly overlap with the integration sites produced by NELF and SPT5, suggesting that Integrator plays a role in promoter proximal regulation of these genes by NELF and DSIF.
In this paper, we report results of an industrial survey conducted among system integrators to understand role of component documentation in the CBS integration phase.
This highlights the need to consider environment, genotype and DNA-M together when seeking to understand the pathogenesis of complex disease, as DNA-M plays a role of integrator of multiple disease pathway signals.
To explore the role of Integrator in the regulation of replication-dependent histones, siRNA-mediated knockdowns of INTS3, NABP2, NABP1, NABP1 and 2, and INTS9 were performed, and replication-dependent histone mRNAs were analyzed for processing, polyadenylation, and total RNA levels by qPCR.
To examine the functional role of Integrator at the JUNB promoter proximal site, cells were depleted of INTS, serum-starved for 16 h, serum-stimulated for 30 min to induce JUNB transcription, and subsequently serum-starved to remove further mitogenic stimulation.
Moreover, our findings also support the argument that endemic super-generalists, such as the bumblebee B. canariensis, play an important role as integrators of aliens into pollinator networks [1].
The Signal transducers and activators of transcription (Stat) family of proteins are transcription factors known for their role as integrators of cytokine and growth factor receptor signaling and are required for cell growth, survival, differentiation, and motility [ 1, 2].
The Stat (signal transducer and activator of transcription) family of proteins are transcription factors known for their role as integrators of cytokine and growth factor receptor signaling and are required for cell growth, survival, differentiation, and motility [ 1, 2].
Finally, the analysis of the modularity of TF pairs in the regulatory network revealed a consistent lack of a shared regulation for CTFPs, which might result in a role as integrators of varied inputs.
The STAT family of proteins are transcription factors, known for their role as integrators of cytokine and growth factor-receptor signaling, which is required for cell growth, survival, differentiation, and motility [ 20- 22].
