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Significantly, these sites directly overlap with the integration sites produced by NELF and SPT5, suggesting that Integrator plays a role in promoter proximal regulation of these genes by NELF and DSIF.
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Finally, the tVOR integrator may play an important role in tVOR motor plasticity.
However, it can be considered that the over-representation of stress- and light-response-related terms in the GO lists may indicate that the active constituents are perceived and the signal is mediated in a similar way as environmental stress signals and therefore general stress-related pathway integrators could play a crucial role in smoke and KAR1 action.
These different routes converge at the regulation of the integrator genes that play a crucial role in the regulation of floral transition.
Notably, beyond its negative impact on elongation through promoter proximal pausing, DSIF is also required for productive elongation, therefore Integrator could conceivably play both a negative and a positive role in regulating transcription elongation.
Finally, I appreciated the chance to see solution use cases for Lenovo's IoT edge technology, and I look forward to seeing more and more of how the company plays the integrator role.
Playing the integrator requires the marketer to command credibility.
For example, the elongated HYPOCOTYL5 (HY5) bZIP protein, an integrator of multiple signaling pathways, plays an important role in photomorphogenic growth and light-regulated gene expression [ 63, 64].
Drawing a clear boundary between these two areas isn't always easy, but players generally enter the Internet consulting field from one of three backgrounds: system integrator, Interactive architect or pure play.
This highlights the need to consider environment, genotype and DNA-M together when seeking to understand the pathogenesis of complex disease, as DNA-M plays a role of integrator of multiple disease pathway signals.
ARNT, on the contrary, appears to be a common dimerization partner for many nuclear transcription factor proteins [ 53- 58], most probably playing the role of crosstalk integrator between diverse signaling pathways.
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