However, we currently lack integrative within-species studies that use quantitative proteomic methods, which allow rich multivariate descriptions of the SFP phenotype, to relate variation in SFP abundance to functional divergence, or SFP effectiveness [ 19].
We first performed this integrative analysis within a system-level framework, using the FEM algorithm to integrate both data types in the context of a comprehensive protein interactome, in an attempt to identify specific gene modules or signalling pathways which are functionally deregulated in ER+ breast cancer as a result of underlying changes in DNA methylation.
Along with these developments it is also important that research pays more attention to how the integrative processes within personality become dysfunctional in personality disorder.
According to the moral psychology outlined in A Treatise of Freewill, the 'hegemonikon' has an integrative function within the soul, combining, on the one hand, the functions of will and reason, and, on the other the lower, animal, appetites of the soul with the higher intellectual functions of the soul.
In this study I apply criteria developed in New Urban Design Theory, a body of thought and practice concerned with modern-day issues of dispersed and low density settlement, to evaluate an architectural complex at the Classic Maya centre of Buenavista del Cayo, Belize, believed to have functioned as an integrative space within the civic entity.
A variety of competences are required, including (a) deep competences in many fields (electrical and mechanical engineering, but also engineering physics and civil engineering); (b) integrative competences within engineering (e.g., mechanical and electrical engineering) and between engineering and non-engineering fields (e.g., meteorology and logistics).
Neuropeptides are critical integrative elements within the central circadian clock in the suprachiasmatic nucleus (SCN), where they mediate both cell-to-cell synchronization and phase adjustments that cause light entrainment.
EDAM's applicability to searching, categorizing and automatic handling of resources has been validated by implementations in eSysbio, Bio-jETI and EMBOSS, demonstrating its relevance to resource catalogues, tool libraries and integrative workbenches within bioinformatics.
When considering the heterogeneity of afferents to the PPN that arise from diverse neuronal systems (reviewed in Martinez-Gonzalez et al. 2011), this suggests an integrative role within PPN microcircuits.
Multi-state characterization described here is largely reflective of evolution and may offer a key feature for integrative systematics within an order whose higher taxa lack definitive features because they have been described through molecular parataxonomy.
