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The integrative template modelling of cTF was carried out by using the MODELLER 26 software.
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12– 15 In light of the known structural information of skeletal muscle thin filament, we have constructed an atomic model of cardiac thin filament in blocked and closed states by using an integrative template-based modelling approach.
The Pirani et al model, which is considered to be the initial template for our integrative modelling, does not have full-length 284 residue long tropomyosin reconstructed, thus we have used the full-length Tm crystal structure 21 to fit the Tm dimer of the model.
We present a template that provides an integrative and simultaneous vision during the design phase of the key simulation design components.
FD-based schemes, owing to their ability to detect scale-invariance provide the template for an ideal integrative scheme that can connect atomic cloud dispositions to macroscopic polarizability.
In addition, we were able to identify several integrative themes that cut across this hierarchal template, due to the process of first condensing, or summarising the data, and further reflecting on the organisation: did the text really represent the codes in the template, did alternative interpretations emerge and were any issues missing from the discussions.
The integrative methodology and resources generated for this study may be used as a template for future genome sequencing studies on larger data sets.
Three building-block solutions are proposed to overcome this transition problem: (1) a 3D-model to support designers in stratifying, elaborating, and formalizing design documents, (2) instructional software templates to support designers in producing software themselves, and (3) an integrative approach to support designers in reusing learning objects.
The buzzwords are "highly integrative".
The integrative dream has faded.
The future of medicine is integrative.
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