To gain further knowledge on this issue, the aim of the present work is to study the pharmacodynamics and pharmacokinetics of diclofenac, a NSAID prototype, using an integrative approach.
This demonstration prototype, kipuMarkers (for knowledge-driven integrative identification of pathway-based biomarkers), allows users to input a gene expression dataset (samples and class labels) and a list of gene/protein sets that can represent known molecular pathways or other types of biologically-meaningful groups, such as co-regulated genes or sets of miRNA targets.
Their teachers guided them through an integrative, project-based learning challenge from concept to prototype to sale in preparation for our school's Student Entrepreneurial Marketplace, a project where they sell actual products to actual customers.
We provide a revised audio-visual integrative model of voice-identity processing which brings together traditional and prototype models of identity processing.
An integrative bottom-up strategy was used to reconstruct a high-quality prototype of HIN based on experimental protein-protein interactions data manually extracted from the literature and integrated from different public databases.
Nevertheless, the regulatory module that we inferred through an integrative genomics approach provides a strong justification for future use of these candidate genes as prototype model for further dissection of the early response ROS-mediated gene regulon by genome-wide transcriptome analysis of transcription factor-overexpressing or knock-out lines.
An integrative approach, involving marketing and management issues on the business side, and product design and prototyping on the technical side, is proposed for the development of chemical-based products.
Our prototype model allows us to explore and understand the key features, physics, and technologies to create an integrative, predictive model of the living human heart.
The designerly way of problem solving is an integrative way of thinking that is characterised by a deep understanding of the user, creative resolution of tensions, collaborative prototyping, and continuous modification and enhancement of ideas and solutions.
The buzzwords are "highly integrative".
