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So far, most the statistical integrative projection-based approaches cited above have been limited to numerical results, and little attention has been paid to either the interpretation of the results or the graphical outputs.
Here we extended those studies to perform a global, integrative analysis of gene expression and projection target correlations in the mouse brain.
To perform an integrative analysis of gene expression patterns and projection targets, the gene expression and connectivity data sets should be mapped to the same space as they are originally provided in different resolutions.
Indeed, they are established peripheral nervous centres with many well-recognized integrative properties such as convergence of central inputs, projections of the visceral inputs at the pre- and post-synaptic level, gating by the central fibres of the projection of the visceral inputs, pacemaker activity [5].
Taken together, these results suggest that the diffuse projections enlarge the terminal field from each cortical region, extending the potential integrative network.
For example, the insular cortex, the main target of the CT projections and known to mediate affective touch signals [ 11, 13, 23, 24], serves important integrative functions for sensory, motor, and emotional signals and seems to be involved in maintaining the homeostatic control over the body [ 22, 25, 26].
We showed through visualization and clustering that both the gene expression and the projection targets data demonstrated significant levels of spatial autocorrelation that needs to be accounted for in the integrative analysis.
The buzzwords are "highly integrative".
My projection".
The future of medicine is integrative.
He is a professor of integrative biology.
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