Based on integrating multiple complementary datasets, integrative computational approaches can use multiple measures to prioritize candidate targets and drugs (Chen et al., 2012b; Gottlieb et al., 2011; Thorn et al., 2010).
Omics sciences are inherently integrative of multiple specialties.
To make the binding sites comparable and the data integrative across multiple samples from different batches, we used uniform pre-processing and peak-calling procedures to identify RBP binding sites from raw CLIP-seq data.
These particles are typically not immunogenic, but are rapidly cleared from the circulation and are non-integrative, so multiple doses of anti-HIV-1 siRNAs must be given [ 149, 153].
In order to decrease the information loss caused by single cutoff value and improve diagnosis efficiency (DE), we explore the integrative application of multiple tumor markers with multiple cutoff values systematically by developing an optimization algorithm named MVMTM.
We present a Bayesian method for the unsupervised integrative modelling of multiple datasets, which we refer to as MDI (Multiple Dataset Integration).
The advantages of integrative analyses of multiple assays are arguably manifold: more fundamental understanding of the complex biology of cancer in its multiple and interrelated facets, power and robustness in tumor classification and prediction of outcome, which cannot be reached by each assay in isolation.
The approaches are integrative in combining multiple goals of agriculture, and confronting these with current or potential performance of agricultural land-use systems at different spatial scales.
In integrative negotiations involving multiple issues, as compared to distributive negotiations involving just one issue, parties often achieve mutual gains by making wise tradeoffs across their differing preferences across issues.
Possible solution: Digital tools for care coordination, similar to a cancer tumor board for treatment planning, more communication with integrative approaches and multiple feedback loops to create a learning system.
