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Methodologies, like co-simulation which allows for parallel simulation at different time-scales in different modules, and modeling environments for integrative models including different types of equations (ODEs, PDEs, SDEs etc) were discussed and evaluated.
In particular, in complex diseases like AD, rather than sticking to the 'well-known', we should aim at integrating both established and emerging knowledge in integrative models.
Sting in the tail And it's the Physiome Project - a worldwide public domain effort, similar to the Genome Project, to provide a computational framework for understanding physiology by developing integrative models at all levels of biological organisation, from genes to the whole organism - that is the sting in the tail.
However, integrative models are beginning to appear.
Two integrative models relying (at least partly) on the use of TTC are presented.
Results demonstrate unexpectedly large differences between countries in the number of integrative models; the nature of agro-ecological or bio-economic relations used, and target audience.
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An integrative model of industry involvement is developed and tested that integrates a multi-level perspective on university industry relations.
MDI adopts a modelling approach distinctly different from those adopted by existing integrative modelling methods.
In breadth it corresponds to the urbane, integrative model that multiculturalism initially proposed.
Still, even bad imperial history provides the French and British with long experience of cohabitation with foreign cultures, whereas the Germans -- who lack this experience -- often seem less able to imagine an integrative model of society.
The integrative model proposes real training developed in professional environments.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com