This integrative approach should shed light on the phenotypes that have participated in human adaptation as well as those involved in human maladaptation and disease.
This paper is not aimed to be a systematic review but rather to present the contours of such integrative research approach in light of the current state of the art around satiety enhancing foods.
Figure 3 shows an integrative model for a light-induced effect on breast cancer etiology [adapted from Stevens (2005)].
A logical and intuitive theoretical leap should be one that considers human actions in light of an integrative scenario.
The purpose of our study is to shed light on the integrative abilities of these networks to obtain a multi-level description of the biological processes within a cellular context.
Although network centrality used alone remains a modest predictor of the impact of positive selection, it could be included in an integrative biology approach to shed light on adaptive processes acting on the genome.
Our subsequent integrative transcriptome analysis shed further light on the link between impairment of TFIIH-mediated functions in placenta and induction of molecular mediators of clinical symptoms of preeclampsia through dysregulation of EGFR- and ATF3-dependent pathways [ 19].
The coding sequences for the 3H6 Fab heavy and light chain were both integrated on a pYX integrative expression vector under control of the constitutive S. cerevisiae TPI1 promoter.
In order to get a more comprehensive view into the expression of the flv genes, we checked the integrative effect of both the carbon and light regimes.
This type of integrative investigation is expected to bring to light new layers of target selection by miRNAs, a better understanding of miRNA maturation and stability, and insights into the regulation of the post-transcriptional gene silencing mechanisms.
