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Diagrams also facilitated performance on measures of integrative knowledge but not on measures of declarative knowledge.

This may be due to a lack of integrative knowledge between scientific disciplines and the inability to discern the strengths of scientific ideas (Nelson 2000).

Based on these findings, this study offers implications for designing Web-based learning environments, engineered to promote integrative knowledge and ill-structured problem solving skills.

However, WSR typically involves challenging research elements (radical disciplinary scope, integrative knowledge production and transdisciplinary design), which are seen by some as intellectually and institutionally flawed.

In an effort to further support the research in this field, we have developed an integrative knowledge base on Marine Sponge Compounds Interactions (Dragon Exploration System on Marine Sponge Compounds Interactions - DESMSCI) as a web resource.

In addition to obtaining a candidate list of the differential genes, integrative knowledge of proteins encoded by mechanosensitive genes and of their interactions with putative partners uncovers the programming of genes functionally involved in paracrine signaling of angiogenesis for bladder SMCs subjected to cyclic stretch (Yang et al., 2008).

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Using integrative analysis techniques, we can integrate knowledge from different levels and obtain a wider view of the system under study.

For example, Hsiao et al.'s interviews with a wide range of practitioners show that successful integration is related to provider attitudes toward integrative medicine, knowledge of integrative medicine, readiness to refer to other practitioners and ability of clinicians to practice more than a single modality.

However, the ease of disseminating, managing, and interpreting massive amounts of omics data would allow for quicker application of integrative omics knowledge to clinical practice.

Inspecting genome databases and expression arrays (of an enzyme, transporter, receptor or ligand) without their integrative functional knowledge with respect to various forms of arthritis will be a starting point for functional genomics in this area.

Despite this limitation, the integrative and knowledge-driven nature of our approach can aid in reducing the possibility of reporting spurious associations.

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