Hence more integrative analysis approaches, integrating data from genetic (SNPs and copy number variations), mRNA expression, protein expression studies should be utilized to better understand the role of genetic variants in drug response.
Finally, Integrative OncoGenomics (IntOGen) is a web available resource integrating data from 6,792 genomes/exome sequencing experiments from 28 cancer types (release 2014.12) [ 63].
All large-scale integrative databases, such as CMRegNet, are facing the same challenge of integrating data from various sources derived by different techniques.
YL performed integrative data analysis.
Integrative data analysis workflow for structural variants.
Due to the complexity of human biology, a bottom-up integrative approach combining data from different levels (genes, molecules, cells, organs, body, etc). is of limited help in understanding disease pathophysiology [42].
Ilya Shmulevich, from the Institute for Systems Biology, introduced integrative analysis of data from TCGA.
A recent integrative analysis of data from The Cancer Genome Atlas suggested that the original 9q31.2 risk locus influences transcript levels of KLF4 (32).
In an integrative approach, PPI data from different sources are evaluated and combined, thus providing maximal likelihood for quality and coverage.
Integrative analysis of data from multiple levels of cell function in the context of a network of several known biochemical interaction types could enable identification of active regulatory paths not limited to a single level of cell function.
