Our incorporation of several replicate high-throughput proteomic data sets illustrates the integrative capabilities of constraint-based models.
Still, often these models are useful for molecular replacement phasing in X-ray crystallography or in combination with other experimental constraints in integrative modeling approaches.
However, these strategies face important technical, socio-economic, and legal constraints that require a more integrative approach for effective conservation.
This was accomplished by an integrative analysis involving high-throughput data and constraint-based modeling to characterize the metabolic activity in Rhizobium etli bacteroids located at the root nodules of Phaseolus vulgaris (bean plant).
Experimentally validated constraint-based models are providing integrative, systems-level views of the functioning of different metabolic networks of various organisms across a wide range of specific conditions (e.g., gene deletions, pharmacological interventions and environmental perturbations) [ 11- 14].
Because of space constraints, we cannot systematically assess these integrative reviews, and our reference list overlooks many worthwhile publications.
It is an inherently integrative approach allowing the incorporation of prior knowledge and constraints.
An aging population and growing number of people with chronic health conditions, alongside resource constraints in health systems, require innovative and integrative approaches to improve systems' efficiency while meeting the needs of individuals and populations.
Second, one of ten leading integrative programs in North America was not assessed due to time constraints.
Depending on the data availability and the type of policy question the user can choose the most appropriate calibration procedure.> These components are solved simultaneously and they are managed by an integrative component (Table 1), containing the objective function and the common constraints.
