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Identification of novel pleiotropic targets that are integrative across multi-organ systems may therefore be effective therapeutic strategies in preventing or reversing heart failure.
To make the binding sites comparable and the data integrative across multiple samples from different batches, we used uniform pre-processing and peak-calling procedures to identify RBP binding sites from raw CLIP-seq data.
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Our research across three very different Indian states Kerala, Meghalaya and Delhi suggests that strategies that attempt to make the health systems receptive to individual integrative efforts may facilitate integration across systems, creating opportunities for greater collaboration, and trust.
Given the interdisciplinary and information rich nature of ICTs, many advocate for school librarians to actively promote their integrative use across the K-12 curriculum.
Chemistry is indeed an immense and rapidly growing discipline with a wealth of disparate computational and database resources which are currently largely isolated and inaccessible to truly integrative queries across the entirety of the chemical (deep) web.
More recently, from his power seat as chair for Veterans Affairs, Sanders promoted a vast expansion of access to integrative services across the Veteran's Health Administration.
The integrative analysis across data sets from multiple centers can reveal potential functional significance and hidden relationships between pathogen and host proteins, thereby providing a systems approach to basic understanding of pathogenicity and target identification.
Meeting the challenges outlined in this paper requires integrative science across scales, disciplines and new partnerships beyond the scientific community.
The most straightforward method for an integrative analysis across datasets is to first compute the age-association genes per dataset and subsequently inspect the overlap of significant results.
To better understand the interplay between genetic, epigenetic, and environmental factors in controlling gene expression in alcoholism, integrative approaches across studies are warranted.
and also have not been systematically normalized and stored in a database for effective comparative and integrative analyses across datasets from different studies.
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