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The tuning of light intensity and sensor integration threshold is quite sensitive.
Second, the integration threshold A should increase with the total Whi5 concentration.
We quantitatively verified the effect of the total Whi5 concentration on the integration threshold A with a strain containing two copies of WHI5.
In light of our findings (Equation (5), Figure 3B,C), it is suggestive that the cell could modulate the integration threshold A, and thus the G1 length, by tuning Whi5 tot.
The third is that reducing Whi5 c by weakening the positive feedback loop increases the integration threshold A (the ODE model predicts that Cln3 c will also change when perturbing the loop strength [ Supplementary file 1A]).
The first is that there is a linear relation between the integration threshold A and the total Whi5 concentration Whi5 tot (a more detailed ODE model predicts that Cln3 c will also change with Whi5 tot [ Supplementary file 1A]).
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We found that cells modulate Whi5 level to set different integration thresholds in different nutrient conditions.
An artificial neuron is a simplistic representation that emulates the signal integration and threshold firing behavior of biological neurons by means of mathematical structures.
And lastly, how to ensure that sustainability context – the integration of thresholds and limits into environmental and social disclosures – remains a high priority in GRI's methodological innovation.
We compared the performance of four distinct families of models to predict the timing of syllable boundaries based on speech envelope or speech audiogram: the Mermelstein algorithm, a Linear Nonlinear (LN) model (a simplified integration-to-threshold algorithm), the entrained theta neural oscillator and a purely rhythmic control model.
In each case, the integration time and threshold of the postsynaptic cell are matched to the statistics of convergent spike trains.
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CEO of Professional Science Editing for Scientists @ prosciediting.com