It involved 8 categories: (A) cell morphology, (B) matrix staining, (C) surface regularity, (D) thickness of the defect, (E) integration of repair tissue with the surrounding articular cartilage, (F) arrangement of repair cartilage, (G) remodeling of subchondral bone, and (H) effects on adjacent cartilage.
Figure 5 Representative sections showing different grades of integration of repair tissue to parent cartilage.
D) Excellent integration between repair tissue (left hand side of arrow) and parent tissue (right hand side of arrow).
Gene expression profiles and histology indicated promotion of a fibrocartilage-like meniscus phenotype, and scaffold integration with repair tissue was observed in the explant model.
We investigated whether incorporation of mesenchymal stem cells (MSCs) into the collagen scaffold improves integration and repair of cartilage defects in a cynomolgus macaque model.
Integration of repaired cartilage with surrounding native cartilage is a major challenge for successful tissue-engineering strategies of cartilage repair.
As the number of gadgets proliferate, consumers will need more help in demonstration, installation, setup, integration, support, repairs and trade-ins — all services that one can catch from Puls.
While this may be essential for host cell viability, it is not clear that it is essential for expression of retroviral genes, thus siRNA screens designed with tat-mediated expression of a reporter gene may not provide a reliable readout for factors involved in post-integration DNA repair.
After ablation of scars, the OECs from LP grafts increased the size of the cellular and axonal zones, more importantly, the absence of scar formation, the integration of repaired tissue with spared tissue, and remyelinated axons in the axonal zone were observed [ 94].
Osteoclast-induced bone remodeling in the bone plate area of treated defects was associated with a 10-fold greater lateral integration of treated repair tissues with the bone plate compared to control defects with detached repair (p<0.05, Figures 11 and 12).
